abstract：:Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), is a traditional Chinese medicine widely used for the treatment of various diseases. In the present study, we examined the antiproliferative effect and apoptosis-inducing activity of paeonol and the crude total glycosides (CTG) extracted from ...

journal_title：Molecular medicine reports

authors： Xing G,Zhang Z,Liu J,Hu H,Sugiura N

更新日期：2010-01-01 00:00:00

abstract：:Buckwheat flour is well known for its highly antioxidative ingredient, rutin. We have undertaken to examine alterations in the characteristics of rutin treated with various proteins. In this study, the radical scavenging activities of a rutin-ovalbumin complex were examined. Dissolved rutin hydrate and ovalbumin were ...

journal_title：Molecular medicine reports

authors： Awatsuhara R,Harada K,Maeda T,Nomura T,Nagao K

更新日期：2010-01-01 00:00:00

abstract：:Dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (MDA-MB-231, MDA-MB-453 and SK-BR-3) and ovarian cancer (SK-OV-3 and OVCAR3) cell lines using the m...

journal_title：Molecular medicine reports

authors： Choi EJ,Kim GH

更新日期：2010-01-01 00:00:00

abstract：:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidat...

journal_title：Molecular medicine reports

authors： Mamori S,Matsushima M,Matsuura T,Tajiri H

更新日期：2009-11-01 00:00:00

abstract：:Liver cirrhosis is frequently accompanied by malnutrition and hypoalbuminemia, which in turn commonly induces ascites in patients with liver cirrhosis. Ascites leads to abdominal distention and appetite loss, resulting in a deteriorated quality of life (QOL). Administration of branched-chain amino acid (BCAA)-rich sup...

journal_title：Molecular medicine reports

authors： Itou M,Kawaguchi T,Taniguchi E,Oku Y,Fukushima N,Ando E,Oriishi T,Uchida Y,Otsuka M,Tanaka S,Iwasaki S,Torii M,Yoshida K,Adachi Y,Suga M,Yoshiyama M,Ibi R,Akiyama Y,Takakura M,Mitsuyama K,Tsuruta O,Sata M

更新日期：2009-11-01 00:00:00

abstract：:Several lysosomal cathepsins have been implicated in a number of diseases, from arthritis to cancer. A recent member of the cathepsin family, cathepsin S (Cat S) has been associated with several types of cancer in humans. However, to date, no report has linked Cat S to human hepatocellular carcinoma (HCC). Here, we in...

journal_title：Molecular medicine reports

authors： Xu J,Li D,Ke Z,Liu R,Maubach G,Zhuo L

更新日期：2009-09-01 00:00:00

abstract：:Chemokines are known to have anti-tumor effects due to their chemoattractant properties, which stimulate the accumulation of infiltrating immune cells in tumors. CCL22 (macrophage-derived chemokine, MDC) attracts killer T?cells, helper T cells and antigen-presenting cells expressing the CCL22 receptor, CCR4. Thus, CCL...

journal_title：Molecular medicine reports

authors： Cho S,Koizumi K,Takeno N,Kato S,Yamada M,Hashimoto I,Sakurai H,Tsukada K,Saiki I

更新日期：2009-09-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical application of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for the detection of malignant lesions. A total of 132 patients with increased levels of blood tumor markers but without a prior history of malignancy were examined. The results of FDG...

journal_title：Molecular medicine reports

authors： Zhan HW,Xu W,Ye XJ,Zhao CL,Zhang H,Li J,Yao Q,Zhang LJ

更新日期：2009-09-01 00:00:00

abstract：:Recent epidemiological studies and animal experiments have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX), the first oxidase in the process of prostaglandin production from arachidonic acid, is the principal target of NSAIDs. Due to i...

journal_title：Molecular medicine reports

authors： Matsuyama M,Yoshimura R

更新日期：2009-07-01 00:00:00

abstract：:Previously, we demonstrated that 8-methoxypsoralen (methoxsalen), a potent human cytochrome P450 2A6 (CYP2A6) inhibitor, strongly suppresses lung adenoma induction by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. In the present study, we examined the inhibitory effects of methoxsalen on the ...

journal_title：Molecular medicine reports

authors： Takeuchi H,Saoo K,Matsuda Y,Yokohira M,Yamakawa K,Zeng Y,Kuno T,Kamataki T,Imaida K

更新日期：2009-07-01 00:00:00

abstract：:Besides known prognostic factors in breast cancer, disseminated tumor cells are regarded as a surrogate marker for minimal residual disease in breast cancer. Their prognostic significance is comparable to that of lymph node status. However, the mechanism by which the primary tumor directs cells to disseminate into lym...

journal_title：Molecular medicine reports

authors： Kasimir-Bauer S,Heubner M,Otterbach F,Kimmig R,Siffert W,Adamzik M

更新日期：2009-07-01 00:00:00

abstract：:The oral fluoropyrimidine S-1 has marked efficacy in treating metastatic colorectal cancer patients. In the present study, we explored the therapeutic potential of combined in vivo treatment in the human colon cancer cell lines COL-1, KM12C and KM20C with consecutive oral S-1 and leucovorin (LV) in 2-week therapeutic ...

journal_title：Molecular medicine reports

authors： Tsukioka S,Uchida J,Tsujimoto H,Nakagawa F,Sugimoto Y,Oka T,Kiniwa M

更新日期：2009-05-01 00:00:00

abstract：:Although imatinib has demonstrated a potent effect on advanced gastrointestinal stromal tumors (GISTs) and has improved the survival of GIST patients, with its prolonged use imatinib resistance is becoming an increasing clinical problem. Mechanisms of secondary resistance are still under investigation. Our study aimed...

journal_title：Molecular medicine reports

authors： Wang CM,Fu H,Zhao GF,Zhou XY,Du CY,Dong RZ,Zhou Y,Shi YQ

更新日期：2009-05-01 00:00:00

abstract：:Malignant mesothelioma (MM) is a highly aggressive neoplasm, which is associated with asbestos exposure. The dysregulated phosphatidylinositol 3-kinase (PI3K)-AKT pathway plays an important role in cell proliferation, survival and motility in various cancers. In this study, we analyzed the activation status and underl...

journal_title：Molecular medicine reports

authors： Suzuki Y,Murakami H,Kawaguchi K,Tanigushi T,Fujii M,Shinjo K,Kondo Y,Osada H,Shimokata K,Horio Y,Hasegawa Y,Hida T,Sekido Y

更新日期：2009-03-01 00:00:00

abstract：:P-glycoprotein (P-gp) overexpression and tumor stem cells are thought to be important factors in the cross-resistance of cancer cells. There have been no studies on whether diallyl trisulfide (DATS) can reverse drug resistance in human osteosarcoma cells. In the present study, we demonstrated that DATS down-regulated ...

journal_title：Molecular medicine reports

authors： Li J,Liu W,Zhao K,Zhang Y,Li X,Yang Q,Li Z,Li J

更新日期：2009-03-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential cell source for the development of therapeutic products. Recent studies have shown that the transplantation of MSCs to damaged organs, including the heart, liver and kidneys, results in the restoration of the damaged tissues. However, the mechanisms underlying this rege...

journal_title：Molecular medicine reports

authors： Cho KA,Ju SY,Ryu KH,Woo SY

更新日期：2009-01-01 00:00:00

abstract：:The hyper-responsiveness of plasma cortisol to vasopressin has been reported in patients with ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) and in certain cases of Cushing's adenomas with overexpression of V1a receptors in the adrenal gland. We previously reported a high prevalence of the ...

journal_title：Molecular medicine reports

authors： Suzuki S,Uchida D,Koide H,Suyama K,Tanaka T,Noguchi Y,Saito Y,Tatsuno I

更新日期：2009-01-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is produced by various types of carcinomas, and is an important factor in the development of bone metastasis. The coexpression of PTHrP and parathyroid hormone/parathyroid hormone-related protein type 1 receptor (PTHR1) in cancer predicts poor patient survival. While genetic...

journal_title：Molecular medicine reports

authors： Miyashita H,Mori S,Fukumoto Y,Sato A,Fukumoto M,Kawamura H

更新日期：2008-11-01 00:00:00

abstract：:Isoniazid (INH) is a drug extensively used as a prophylactic and therapeutic agent for human tuberculosis (TB). INH is metabolized by the enzymatic activity of N-acetyltransferase 2 (NAT2). Human NAT2, encoded by a highly polymorphic gene, is involved in the biotransformation of xenobiotics, including drugs and certai...

journal_title：Molecular medicine reports

authors： Díaz-Molina R,Cornejo-Bravo JM,Ramos-Ibarra MA,Estrada-Guzmán JD,Morales-Arango O,Reyes-Báez R,Robinson-Navarro OM,Soria-Rodríguez CG

更新日期：2008-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection induces not only chronic liver disease, but also extrahepatic manifestations such as thyroid disease and oral cancer. Thyroid dysfunction is also a complication known to be associated with interferon (IFN) therapy for HCV infection. We report on a 69-year-old Japanese man who develope...

journal_title：Molecular medicine reports

authors： Nagao Y,Hiromatsu Y,Nakashima T,Sata M

更新日期：2008-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells invade interstitial connective tissue and proliferate. Suppression of this invasion and proliferation could serve as a novel molecular therapy. Since insulin-like growth factor-I receptor (IGF-IR) interacts with components of interstitial tissue, we focused on the inhibition of IGF...

journal_title：Molecular medicine reports

authors： Tomizawa M,Yokosuka O

更新日期：2008-09-01 00:00:00

abstract：:Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' ...

journal_title：Molecular medicine reports

authors： Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

更新日期：2008-09-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by ace...

journal_title：Molecular medicine reports

authors： Choi GH,Park HS,Kim KR,Choi HN,Jang KY,Chung MJ,Kang MJ,Lee DG,Moon WS

更新日期：2008-07-01 00:00:00

abstract：:A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 1...

journal_title：Molecular medicine reports

authors： Shibata T,Arisawa T,Tahara T,Hirata I,Nakano H

更新日期：2008-07-01 00:00:00

abstract：:Serious diabetic complications affect millions of patients worldwide. Skeletal muscle represents the largest insulin-regulated glucose sink in the body, making insulin resistance and abnormal glucose disposal in muscle fibres a critical aspect of diabetes mellitus. Advances in the biomedical analysis of the molecular ...

journal_title：Molecular medicine reports

authors： Mulvey C,Mullen E,Ohlendieck K

更新日期：2008-05-01 00:00:00

abstract：:Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

journal_title：Molecular medicine reports

authors： Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

更新日期：2008-05-01 00:00:00

abstract：:The ZIC genes comprise a family of transcriptional factors associated with neural tube defects (NTDs) in mice and with holoprosencephaly in humans. An allelic variant of ZIC2, a CAC repeat within the first exon, was reported in association with an increased risk of non-syndromic NTDs in patients with a Hispanic ethnic...

journal_title：Molecular medicine reports

authors： Costa-Lima MA,Meneses HN,El-Jaick KB,Amorim MR,Castilla EE,Orioli IM

更新日期：2008-05-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：Molecular medicine reports

authors： Steelman LS,Navolanic PM,Franklin RA,Bonati A,Libra M,Stivala F,Martelli AM,McCubrey JA

更新日期：2008-03-01 00:00:00

abstract：:SC1, an immunoglobulin superfamily cell adhesion molecule, is expressed in embryonic tissues and plays an important role in development through its cell adhesive activity. SC1 is also found in a variety of tumors and its expression is associated with a poor prognosis. The expressional patterns of SC1 were examined in ...

journal_title：Molecular medicine reports

authors： Adachi K,Hagimori K,Kato H,Fukuda K,Kikuta M,Tsukamoto Y

更新日期：2008-03-01 00:00:00

abstract：:More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence ...

journal_title：Molecular medicine reports

authors： Perletti G,Vral A,Patrosso MC,Marras E,Ceriani I,Willems P,Fasano M,Magri V

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this study was to assess the efficacy and predictive biomarkers of combination docetaxel-trastuzumab in a neoadjuvant setting by means of a phase II trial. Women with histologically-confirmed advanced invasive breast cancer whose tumours overexpressed HER-2 received 4 cycles of docetaxel (70 mg/m2 every...

journal_title：Molecular medicine reports

authors： Kurosumi M,Tabei T,Sano M,Honma K,Yanagita Y,Yamamoto N,Inoue K,Sato N,Kimura M

更新日期：2008-01-01 00:00:00